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Services / Cutera® GenesisPlus Laser

Cutera® GenesisPlus Laser

One Laser, Lasting Solutions: The Modern Treatment for Your Toughest Foot Problems

Discover Cutera® GenesisPlus™ — a single, revolutionary laser therapy clinically proven to safely and effectively treat toenail fungus, plantar warts, neuromas, and scars without needles or downtime.

Finally, a Real Answer to Your Frustrating Foot Condition

Whether you’ve been hiding embarrassing toenail fungus for years, battling a stubborn plantar wart that won’t go away, or suffering from the daily pain of a neuroma, you know how much a persistent foot problem can impact your life.

You’ve likely tried the messy creams, the ineffective home remedies, or have been told to just “live with it.” The reason these approaches fail is simple: they don’t address the problem at its source. To achieve a real, lasting solution, you need a technology powerful enough to solve the problem from within.

Cutera GenesisPlus: A Technology Proven Across the Board

At San Mateo Podiatry Group, we invested in the Cutera GenesisPlus™ because of its unparalleled versatility and proven clinical results. This advanced, FDA-cleared Nd:YAG laser uses targeted light energy to safely eliminate the root cause of your condition without harming the surrounding healthy tissue.

The clinical data on this specific laser technology is why it is the gold standard for non-invasive treatment. The results speak for themselves:

  • Painful Neuromas: Clinical research shows an 81%1 to 95%2 effectiveness rate in resolving pain, with 84% (1) patient satisfaction. High-level research identifies this as a premier non-invasive treatment 3 , avoiding the risk of surgery-related stump neuroma. Objective proof shows pain is significantly decreased or absent in 94% of lesions4 and that neuroma size can shrink by 44% on ultrasound (4).
  • Plantar Warts (Verrucae): Achieve an incredible 96%5 clearance rate against stubborn plantar warts, often after just 2 to 3 treatment sessions. This laser spares surrounding tissue, unlike cryotherapy
  • Toenail Fungus (Onychomycosis): With an 80% effective rate for mycological clearance6 after two sessions, the GenesisPlus is superior to oral antifungals for safety and topicals for efficacy.

The Clear Choice for a Modern Solution

  • FDA approved since 2011
  • Advanced laser energy treats toenail fungus, warts, neuromas, and scar tissue.
  • Fast & Painless: Most treatments are completed in under 15 minutes with virtually no discomfort.
  • Absolutely No Downtime: Walk out of our office and immediately return to life, work, and exercise.
  • Safe & Chemical-Free: Avoid the potential side effects of oral medications or the risks of surgery.

Take the First Step to Resolving Your Foot Problem

You’ve already spent enough time dealing with this issue. Making the decision to use a proven, effective technology is the most important step you can take towards getting back to a pain-free, confident life.

The process begins with a comprehensive consultation to diagnose your condition and determine if you are a candidate for our advanced laser therapy.

Stop the cycle of frustration. Schedule your consultation today to find out how the Cutera GenesisPlus™ laser can help you. Call 650-342-2420 or book your appointment online now!

Cutera GenesisPlus® Laser Treatment for toenail fungus

How We’re Different

The Doctors and team of San Mateo Podiatry Group proudly offer patients the latest advanced, safe and effective treatments for foot and ankle problems.

  • Same day consultations and treatments are generally available
  • Most procedures can be completed with little to no discomfort.
  • Generally, patients can return to work, sports and exercise immediately.

Trust the Experience, Experience The Difference

Founded in 1917, San Mateo Podiatry Group is the San Francisco Peninsula’s Premier Foot and Ankle Specialty Practice, delivering a tradition of excellence in foot and ankle care. The Doctors of San Mateo Podiatry Group are Board Certified Podiatric Foot and Ankle Surgeons use the latest technology, proven research, and experience to deliver great results for patients.

Our proven process delivers state of the art foot and ankle care to our clients, to help them become their best selves.

Learn more about Doctors of Podiatric Medicine: The experts in medical and surgical care of the foot and ankle

  1. Gatt, A. et al. (J Am Podiatr Med Assoc, 2017) 2 (Prospective Study) ↩︎
  2. Bocian, D. (dabyag.com, 2025) 5 (Clinical Experience/Case Reports) ↩︎
  3. Thomson, L. et al. (J Foot Ankle Res, 2018) Level 1 (Systematic Review) ↩︎
  4. Gimber et al. (AJR, 2017) 4 (Retrospective Study) ↩︎
  5. Han, T. Y. et al. (J Korean Med Sci, 2009) 4 (Case Series) ↩︎
  6. Gupta, A.K. et al. (Benha Medical Journal, 2022) 2 (Clinical Study) ↩︎

Frequently asked questions

What causes toenail fungus?

Nail infections are caused by fungi that thrive in moist and dark environments. Toenail fungus, also known as onychomycosis, is a condition in which the toenails become yellow or discolored, thick and brittle as a result of a fungal infection.

These infections feed off the keratin found in the toenails and the skin around the toes.

Because fungus is so prevalent, anyone can develop fungal toenail infections.

Studies have shown that as many as 1 in 3 people have been affected by this problem.

How would I know if I have toenail fungus?

There are other conditions, such as psoriasis, that can change nail appearance similar to onychomycosis, or nail fungus. In those cases, additional testing such as a nail culture or biopsy is necessary to confirm the diagnosis.

If you suspect you have a fungal infection of the toenails, Dr. Metaxas and his team can make an accurate diagnosis. Call our offices today for an appointment.

What does nail fungus look like?

Generally, patients report the following:

- Discolored nails
- Yellow streaks under the nail
- Distorted or thickened nails
- Brittle, crumbly or ragged nail
- Nails separated from the underlying skin
- Buildup of debris (nail fragments, skin) under the nail
- White spots or streaks on the nail surface

For reference, you can also look at our before and after gallery, above.

What treatments are available?

1. Topical Medications: Generally had low rates of effectiveness when used in isolation

2. Systemic Medications

Lamisil (terbinifine) – a safe and effective (up to 60%) medication taken orally, requires blood testing depending on how it is dosed. Early studies of Terbinifine and it’s FDA clearance required routine blood testing during treatment.

Subsequent studies have shown that this is not necessary depending on dosing patterns.

3. Cutera GenesisPlus Laser Treatment – Laser Treatment for Toenail Fungus

Cutera GenesisPlus laser treatment can safely eliminate toenail fungus infection using modern laser technology and is FDA approved to treat toenail fungus, or onychomycosis.

Studies have shown the laser to be up to 85% effective in reducing the presence of the fungal infection that causes onychomycosis.

No one treatment option is guaranteed to relieve infection, but our Doctors can evaluate your individual case and recommend the one that's best for you!

Which model or manufacturer of laser do you use?

Our practice exclusively uses Cutera GenesisPlus laser treatment to safely eliminate toenail fungus infection. The GenesisPlus laser is FDA approved to treat toenail fungus, or onychomycosis.

Studies have shown the laser to be up to 85% effective in reducing the presence of the fungal infection that causes onychomycosis.

Is the laser FDA Approved?

Yes, The Cutera GenesisPlus laser is FDA approved to treat toenail fungus, or onychomycosis.

Studies have shown the laser to be up to 85% effective in reducing the presence of the fungal infection that causes onychomycosis.

What is the success rate associated with laser treatment?

Studies have shown the laser to be up to 85% effective in reducing the presence of the fungal infection that causes onychomycosis.

Long-pulse Nd:YAG 1064-nm laser treatment for onychomycosis.

Zhang RN, Wang DK, Zhuo FL, Duan XH, Zhang XY, Zhao JY. Chin Med J (Engl). 2012 Sep;125(18):3288-91.

Treating onychomycoses of the toenail: clinical efficacy of the sub-millisecond 1,064 nm Nd: YAGlaser using a 5 mm spot diameter.

Kimura U, Takeuchi K, Kinoshita A, Takamori K, Hiruma M, Suga Y. J Drugs Dermatol. 2012 Apr;11(4):496-504.

Laser treatment of onychomycosis using a novel 0.65-millisecond pulsed Nd:YAG 1064-nmlaser.

Hochman LG. J Cosmet Laser Ther. 2011 Feb;13(1):2-5. doi: 10.3109/14764172.2011.552616. Epub 2011 Jan 21.

Laser treatment of onychomycosis: an in vitro pilot study.

Hees H, Raulin C, Bumler W. J Dtsch Dermatol Ges. 2012 Dec;10(12):913-8. doi: 10.1111/j.1610-0387.2012.07997.x. Epub 2012 Aug 17. English, German.

What does the treatment package involve?

We always start with an initial consultation to determine if treatment is correct for your case and if needed, additional therapies.
The treatment packages include three laser treatments, generally spaced 1-2 months apart.
The consultations are billed to your medical insurance and are in addition to the laser treatment package.

How long does it take to see results?

Nails grow very slowly, up to one millimeter per month. We generally advise patients that it can take four to six months to see the early signs of clear nail growth. Complete nail clearance can take up to twelve months or longer.

Does health insurance pay for laser treatment? How much does it cost?

Health insurance will pay for consultations however, does not pay for laser treatment; Treatment package investments range from $1495 to $2995.

  • Advanced Podiatry
  • At-Risk Foot Care
  • Swift® Microwave Therapy
  • Biopsy Procedures
  • Cutera® GenesisPlus Laser
  • PedCat® Foot & Ankle Imaging
  • Custom Foot Orthotics
  • Regenerative Laser Therapy
  • Regenerative Magnetic Therapy
  • Regenerative Shockwave Therapy
  • Minimally Invasive Bunion Surgery
  • Treace Medical Lapiplasty® for Bunions

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San Mateo Podiatry Group
1750 El Camino Real, Suite 106
Burlingame, CA 94010

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